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Rates for preterm birth range between 6% and 12% in developed countries, and
can be higher in developing countries. About one third of these are associated
with preterm prelabour rupture of membranes (pPROM). One of the factors associated
with preterm delivery is infection, which may also lead to infection of the
uterus and fetus. Moreover, neonatal infection is one of the leading causes of
neonatal mortality in developing countries.
Key messages
􀃎 Preterm birth is the leading cause of neonatal mortality both in developed
and developing countries.
􀃎 Antibiotic administration following pPROM reduces chorioamnionitis, delays
delivery and reduce the risk of serious neonatal morbidity.
􀃎 The antibiotic Co-amoxiclav was associated with an increased risk of neonatal
necrotising enterocolitis.

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