Period: 2009 – ongoing

Researchers: IECS: Vilma Irazola, Rosana Poggio, Laura Gitierrez, Natalia Elorriaga, Pablo Gulayin; San Carlos de Bariloche Clinic: Matías Calandrelli. Municipality of Marcos Paz: Nora Mores, Héctor Olivera. Universidad de la Frontera (Temuco): Fernando Lanas, Pamela Serón. University of the Republic (Uruguay): Jacqueline Ponzo, Aníbal Manfredi. Tulane University (New Orleans, United States): Jiang He, Lydia Bazzano.

Brief

This is a study designed to investigate the prevalence and distribution of risk factors, as well as the incidence of cardiovascular disease in the general population.

Objectives

To investigate the prevalence and distribution of risk factors, as well as the incidence of cardiovascular disease in the general population of four cities in the Southern Cone of Latin America.

Summary

The studio CESCAS I is a prospective population cohort study whose objective is to determine the prevalence and distribution of risk factors for cardiovascular disease, as well as the incidence of cardiovascular disease in the general population of four cities in the Southern Cone of Latin America, Marcos Paz and Bariloche ( Argentina), Temuco (Chile) and Pando-Barros Blancos (Uruguay). The study used multistage random sampling and included more than 7,500 adults of both sexes, between 35 and 74 years of age, who were evaluated through questionnaires and physical and laboratory measurements. It began in 2009 and is currently in the follow-up phase.

Results

85% of adults in our population consumed less than 5 servings of fruits and vegetables per day, 35.2% reported a low level of physical activity, and 29.7% smoked. The prevalence of global obesity, central obesity, hypertension, chronic kidney disease, dyslipidemia, diabetes, and metabolic syndrome was 35.7%, 52.9%, 40.8%, 2.0%, 58.4%, 12.4%, and 37.4%, respectively. The proportion of individuals with ≥3 cardiovascular risk factors, including low consumption of fruits and vegetables, insufficient physical activity, smoking, obesity, central obesity, chronic kidney disease, dyslipidemia and diabetes reached 68.3%.

Finance

National Heart, Lung, and Blood Institute (NHLBI)/NIH

Study design

Prospective population cohort study.

Derivative publications

Rubenstein A, Irazola V, Poggio R, Bazzano L, Calandrelli M, Lanas Zanetti F, Manfredi JA, Olivera H, Seron P, Ponzo J, He J. Detection and follow-up of cardiovascular disease and risk factors in the Southern Cone of Latin America: the CESCAS I study. BMJ open.JUNE 2011.

Rubenstein A, Irazola VE, Calandrelli M et. to the. Multiple cardiometabolic risk factors in the Southern Cone of Latin America: A population-based study in Argentina, Chile, and Uruguay. Int J Cardiol. 2015 Jan 27;183C:82-88. doi:10.1016

Rubenstein A, Irazola VE, Poggio R, Lanas F, Calandrelli M, Ponzo J, Olivera H, Seron P, Bazzano L, Guterrez L, He J. Prevalence, Awareness, Treatment, and Control of Hypertension in the Southern Cone of Latin America. Circulation 2013 ; 127: AP317

Rubinstein A, Irazola VE, Poggio R, Lanas F, Calandrelli M, Ponzo J, Olivera H, Seron P, Bazzano L, Gutierrez L, He J. Prevalence, Awareness and Control of Diabetes Mellitus in the Southern Cone of Latin America. Circulation 2013 ; 127: AP445

Irazola V, Rubinstein A, Poggio R, Gutierrez L, Beratarrechea A, Calandrelli M, Olivera H, Lanas F, Seron P, Ponzo, J, He J. Prevalence of Metabolic Syndrome in the Southern Cone of Latin America. Ann Nutr Metab 2013;63(suppl 1):1–1960. (DOI:10.1159/000354245) PO2066.

Elorriaga,N, Irazola VE, Gutierrez L, Defagó MD, Poggio R, Rubinstein A. Diet patterns in Argentinean adults. Circulation. 2014;129:AP419

Defagó D, Elorriaga N, Irazola V, Rubinstein A. Influence of food patterns on endothelial biomarkers: a systematic review. J Clin Hypertens. 2014:1–7.

Elorriaga N, Poggio R, Gutierrez L, Irazola V, Defago DD, Cormick G, Danaei G, Mozaffarian D, Rubinstein A. Associations of Yerba Mate Tea Drinking With Blood Lipids, Apolipoproteins, and C-Reactive Protein Among South American Adults. Circulation. 2015;131:AP215

Poggio R, Matta MG, Serón P, Gutierrez L, Irazola V, Rubinstein A. Prevalence, Patterns and Correlates of Physical Activity Among the Adult Population of Four Cities in the Southern Cone of Latin America: Results from the CESCAS I study. Circulation. 2015;131:AP278// NCD Risk Factor Collaboration (NCD-RisC)

 Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4·4 million participants. The Lancet. Volume 387, No. 10027, p1513–1530, 9 April 2016.

– Poggio R, Serón P, Matías Calandrelli, Ponzo J, Mores N, Matta MG, Gutierrez L, Chung-Shiuan c, Lanas F,He J,Irazola V,Rubinstein A, Bazzano L. Prevalence, Patterns, and Correlates of Physical Activity Among the Adult Population in Latin America: Cross-Sectional Results from the CESCAS I Study. Global Heart. Volume 11, Issue 1, March 2016, Pages 81–88.e1

– Irazola VE, Gutierrez L, Bloomfield G, Carrillo-Larco RM, Dorairaj P, ‖Gaziano, Levitt NS, Miranda J, Bernabe Ortiz A, Steyn K, Wu Y, Xavier D, Yan L, He J, Rubinstein A. Hypertension Prevalence, Awareness, Treatment, and Control in Selected LMIC Communities: Results From the NHLBI/UHG Network of Centers of Excellence for Chronic Diseases. Global Heart. Volume 11, Issue 1, March 2016, Pages 47–59

– Poggio, Rosana et al. Prevalence, Patterns, and Correlates of Physical Activity Among the Adult Population in Latin America. Global Heart, Volume 11, Issue 1, 81 – 88.e1

– Carrillo-Larco, Rodrigo M. et al.Prevalence of Pragmatically Defined High CV Risk and its Correlates in LMIC. Global Heart, Volume 11, Issue 1, 27 – 36

–Shen, Jia et al. A Multiethnic Study of Pre-Diabetes and Diabetes in LMIC. Global Heart, Volume 11, Issue 1, 61 – 70

– Irazola, Vilma E. et al.. Hypertension Prevalence, Awareness, Treatment, and Control in Selected LMIC Communities. Global Heart, Volume 11, Issue 1, 47 – 59

– Patel, Shivani A. et al. Obesity and its Relation With Diabetes and Hypertension. Global Heart, Volume 11, Issue 1, 71 – 79.e4

– Gaziano, Thomas A. et al. Comparison of Nonblood-Based and Blood-Based Total CV Risk Scores in Global Populations. Global Heart, Volume 11, Issue 1, 37 – 46.e2

– Bloomfield, Gerald S. et al. Training and Capacity Building in LMIC for Research in Heart and Lung Diseases. Global Heart, Volume 11, Issue 1, 17 – 25

– Rubinstein A, Irazola V, Calandrelli M et al. Prevalence, Awareness, Treatment, and Control of Hypertension in the Southern Cone of Latin America. Am J Hypertens (2016) doi: 10.1093/ajh/hpw092

– Fernando Lanas, Lydia Bazzano, Adolfo Rubinstein, Matias Calandrelli, Chung Shiuan Chen, Natalia Elorriaga, Laura Gutierrez, Jose A. Manfredi, Pamela Seron, Nora Mores, Rosana Poggio, Jacqueline Ponzo, Hector Olivera, Jiang He, Vilma E. Irazola . Prevalence, Distributions and Determinants of Obesity and Central Obesity in the Southern Cone of America. PLOS ONE | DOI:10.1371/journal.pone.0163727. October 14, 2016

– NCD Risk Factor Collaboration (NCD-RisC).Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19 1 million participants. The Lancet. DOI: http://dx.doi.org/10.1016/S0140-6736(16)31919-5. November 2016.

   Seron P, Irazola V, Rubinstein A, Calandrelli M, Ponzo J, Olivera H, Gutierrez L, Elorriaga N, Poggio R, Lanas F. Ideal Cardiovascular Health in the southern cone of Latin America. Public Health. 2018 Feb 7;156:132-139