Period: 2012-2014 The main objective is to evaluate a complex intervention for the identification of women at high risk for preterm birth and the administration of antenatal corticosteroids to reduce neonatal mortality. This cluster RCT is on-going in more than a 100 communities and facilities in Argentina, Guatemala, India, Kenya, Pakistan, and Zambia. The study is  coordinated by IECS under the NICHD’s Global Network for Women’s and Children’s Health Research (GN). Researchers Althabe F, Mazzoni A, Gibbons L, Belizán J, Cormick G. Abstract This cluster RCT is ongoing in more than a 100 communities and facilities in Argentina, Guatemala, India, Kenya, Pakistan, and Zambia under the NICHD’s Global Network for Women’s and Children’s Health Research (GN). The main objective is to evaluate a complex intervention for the identification of women at high risk for preterm birth and the administration of antenatal corticosteroids to reduce neonatal mortality. For this evaluation, the study relies on a prospective “Maternal and Perinatal Health Registry” implemented since 2008, in all GN sites, to provide maternal and perinatal population-based statistics. Up to May 2013 the Registry enrolled 352,524 pregnant women and women at delivery, 13766 of them in Argentina, with 99% follow up at 42 days postpartum. Objetives To reduce neonatal mortality through increasing the rate of Celestone® administration to eligible women. Financing The National Institute of Child Health and Human Development Study Type Cluster Randomized Control Trial. Publications Althabe F, Belizán JM, McClure EM, Hemingway-Foday J, Berrueta M, Mazzoni A, Ciganda A, et al. A population-based, multifaceted strategy to implement antenatal corticosteroid treatment versus standard care for the reduction of neonatal mortality due to preterm birth in low-income and middle-income countries: the ACT cluster-randomised trial. Lancet. 2015 Feb 14;385(9968):629-39. doi: 10.1016/S0140-6736(14)61651-2. Epub 2014 Oct 15. [Ver resumen] http://www.ncbi.nlm.nih.gov/pubmed/25458726 Althabe F, Belizán JM, Mazzoni A, Berrueta M, Hemingway-Foday J, Koso-Thomas M, McClure E, Chomba E, Garces A, Goudar S, Kodkany B, Saleem S, Pasha O, Patel A, Esamai F, Carlo WA, Krebs NF, Derman RJ, Goldenberg RL, Hibberd P, Liechty EA, Wright LL, Bergel EF, Jobe AH, Buekens P. Antenatal corticosteroids trial in preterm births to increase neonatal survival in developing countries: study protocol. Reprod Health. 2012 Sep 19;9:22. doi: 10.1186/1742-4755-9-22.  [Ver texto completo] file:///C:/Users/Maria%20Belizan/Downloads/1742-4755-9-22.pdf